I'm having trouble even getting L.A. Noire to start on my 5x1P. It just crashes when I try to get the game going with whatever fixes exist. Might try 3x1P here sometime and see if it's an aspect ratio issue or a vertical resolution issue. I'm expecting vertical resolution issues as 1920 vertical lines is a lot more than some games expect. Skyrim, for instance, has a "level up" notice that's supposed to sit underneath the 1080 line on a normal screen. Strange thing is, the "level up" notice isn't even used in the game and no one seems to recognize where it comes from. Just another good reason not to leave junk in games.
Also, I'm only familiar with MSAA and FXAA. The first one is classic anti-aliasing. I think what this does is it calculates the percentages of the sources of color for a pixel. Such that if you have multiple polygonal lines crossing over a pixel, it averages together the colors to give you a better perception of all of them. FXAA is also called "blurring" by people that are MSAA enthusiasts. It's a more approximated form of anti-aliasing and is far more performance efficient. I think it functions off of finding contrasts in the 2D image (it's a post-processing technique) and blurring together any sharp contrasts. When you have a lot of excess resolution, I recommend FXAA over MSAA as MSAA will wreck your system and you have so much excess resolution that any "blurring" from FXAA isn't noticeable. Though, if you want to get really crazy, you could do both FXAA and MSAA, but your machine is liable to slow to a crawl.
Hope that cleared it up without too much rambling. ;)
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