1280x768 (1.67:1) is not an available resolution to me or even one of the aspect ratio profiles in the game options, so I guess no it's not available without editing.
1280x720 is available, as is 1280x800. Regrettably, precisely 1280x768 is not. If you are letterboxing, I would suggest one of the aforementioned resolutions. If 1280x768 is your native screen resolution, definitely edit the ini files.
The 2D screens are Hor+ without .ini editing, but they are also stretched at the same time. Circles appear oval shaped. Who knows why they did this.
With latest patches, they should not be stretched. They were not for me ... however... several 2D screens have a mix of Hor+(background) and Ver-(foreground). Unless you are going multi monitor, the Ver- does not cut into the working area of the menu/minigame. It means for hacking, the black/green working area of the screen touches top and bottom of your display but is not cut off. Lockpicking is a little more controversial, as you see less of the hand picking the lock. The alternative, however, is enough dead space to really look kind of wrong.
I believe these are intentional choices (albeit made without consideration for multi monitor configs). There is an .ini setting to zoom them as you see fit.
In my opinion, this game has done a very good job with widescreen support, offering letterboxed modes for people who's screens aren't as wide as they would like. I haven't seen a lot of games offer that option.
Agreed. I also strongly suspect this is part of why they went Ver- on the menus mentioned. If someone has a non widescreen monitor, letterboxes, then gets a menu, it could get pretty tiny.